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Organic compounds that contain a carbon atom bonded to a halogen atom, and an oxygen atom via a double bond; commonly derived from an oxoacid by replacing a hydroxyl group with a halogen atom.
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Umeclidinium bromide is a novel mAChR antagonist with high affinity for cloned human M1-M5 mAChRs. It exhibits slow functional reversibility at cloned human M3 mAChRs and at endogenous mAChR in isolated human bronchus. It also inhibits the human ether-a-go-go-related gene channel tail current in human embryonic kidney 293 cells.
Target: mAChR
Pathway: GPCR/G protein, neuronal signaling
Inhibits human ether-a-go-go-related gene channel tail current
Demonstrates slow functional reversibility at M3 mAChRs
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Fentonium bromide is an anticholinergic and antispasmodic research compound used in pharmacological studies of gastrointestinal and neurological conditions, including unstable bladder. Supplied as the bromide salt in solid form, it is commonly used as a tool compound in studies of muscarinic acetylcholine receptors and is typically dissolved in DMSO for experimental use.
CAS 5868-06-4
Chemical formula C31H34BrNO4
Molecular weight 564.51 g/mol
Purity 98.75%
Form bromide salt, solid
Solubility soluble in DMSO
Intended use research reagent targeting muscarinic acetylcholine receptors
Available in small quantities such as 5 mg
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Tiotropium bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. It is a 24-hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease. It improves symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure.
Targets mAChR
Involved in GPCR/G Protein and neuronal signaling pathways
Long-acting, stops signaling between neurons and leads to muscle relaxation
Used in the management of chronic obstructive pulmonary disease
Improves symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure
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Chemical. CAS 155863-03-9. Formula C29H24BrN3O6. MW 590.42. Synthetic. New class of highly photostable, water soluble fluorescent labels with large Stokes shift, high QY in aqueous media and pH tolerance.
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Chemical. CAS 155863-03-9. Formula C29H24BrN3O6. MW 590.42. Synthetic. New class of highly photostable, water soluble fluorescent labels with large Stokes shift, high QY in aqueous media and pH tolerance.
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N4-Benzoyl-2 -O-methylcytidine is a natural cytidine nucleoside analog Cytidine analogs have the mechanism of inhibiting DNA methyltransferase (such as Zebularine (HY-13420)) and have potential antimetabolite and antitumor activities[1][2]
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